Serum Clusterin as a Tumor Marker and Prognostic Factor for Patients with Esophageal Cancer

Table 3

Prognostic factors for ESCC patients.

(a) Univariate analysis

Factor	value
Age	0.897
Gender (male versus female)	0.102
Tumor location	0.460
Upper versus lower	0.813
Middle versus lower	0.215
Pathological stage	0.001
Stage I versus stage III	0.037
Stage II versus stage III	0.001
Lymph node metastasis number	0.009
Lymph node yield; Clusterin concentration (<500 versus >500 μg/mL)	0.525; 0.392

(b) Multivariate analysis

Factor	P value	HR	95% CI
Lymph node metastasis number	0.517	0.919	0.847–1.807
Gender (male versus female)	0.040	8.466	1.106–64.800
Pathological stage	<0.0001
Stage I versus III	0.006	0.113	0.024–0.538
Stage II versus III	<0.0001	0.145	0.050–0.418
Clusterin concentration; (<500 versus >500 μg/mL)	0.030	2.835	1.107–7.263

ESSC: esophageal squamous cell carcinoma; HR: hazard ratio; CI: confidence interval.