High SHIP2 Expression Indicates Poor Survival in Colorectal Cancer

Table 2

Univariate and multivariate analyses of prognostic factors in 102 CRC patients for overall survival.

	Univariate analysis			Multivariate analysis
	HR		95% CI	HR		95% CI
SHIP2 expression
High versus low	2.20	0.017^*	1.151–4.189	2.05	0.040^*	1.031–3.820
Gender
Male versus female	1.44	0.281	0.744–2.774
Age (years)
≥60 versus <60	0.83	0.562	0.439–1.565
Tumor size (cm)
≥5 versus <5	1.29	0.410	0.701–2.388
Tumor location
Colon versus rectum versus ileocecal junction	0.68	0.354	0.306–1.528
Histological type
Adenocarcinoma versus nonadenocarcinoma	1.05	0.960	0.145–7.662
Tumor differentiation
Well and moderately versus poorly	1.50	0.413	0.569–3.943
Serum CEA level (ng/mL)
≥15 versus <15	2.33	0.057	0.976–5.573
Lymph node metastasis
Positive versus negative	2.91	0.001^*	1.573–5.408	1.26	0.668	0.443–3.568
Distant metastasis
Positive versus negative	7.06	0.001^*	3.687–13.521	5.09	0.001^*	2.034–12.736
TNM stage
Stages I-II versus stages III-IV	0.25	0.001^*	0.129–0.466	0.72	0.638	0.188–2.789

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