Table of Contents Author Guidelines Submit a Manuscript
Disease Markers
Volume 2014, Article ID 232837, 7 pages
http://dx.doi.org/10.1155/2014/232837
Research Article

MicroRNA-21 Promotes Cell Growth and Migration by Targeting Programmed Cell Death 4 Gene in Kazakh’s Esophageal Squamous Cell Carcinoma

1Clinical Medical Research Institute, First Affiliated Hospital of Xinjiang Medical University, Xinjiang Uygur Autonomous Region, Urumqi 830054, China
2State Key Lab Incubation Base of Xinjiang Major Diseases Research, First Affiliated Hospital of Xinjiang Medical University, Xinjiang Uygur Autonomous Region, Urumqi 830054, China

Received 12 May 2014; Revised 15 September 2014; Accepted 30 September 2014; Published 21 October 2014

Academic Editor: Fabrizia Bamonti

Copyright © 2014 Tao Liu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. P. C. Enzinger and R. J. Mayer, “Esophageal cancer,” The New England Journal of Medicine, vol. 349, no. 23, pp. 2241–2252, 2003. View at Publisher · View at Google Scholar · View at Scopus
  2. R. Lambert and P. Hainaut, “The multidisciplinary management of gastrointestinal cancer. Epidemiology of oesophagogastric cancer,” Best Practice & Research Clinical Gastroenterology, vol. 21, pp. 921–945, 2007. View at Google Scholar
  3. S. Zheng, L. Vuitton, I. Sheyhidin, D. A. Vuitton, Y. Zhang, and X. Lu, “Northwestern China: a place to learn more on oesophageal cancer. Part one: behavioural and environmental risk factors,” European Journal of Gastroenterology & Hepatology, vol. 22, no. 8, pp. 917–925, 2010. View at Publisher · View at Google Scholar · View at Scopus
  4. S. Zheng, L. Vuitton, I. Sheyhidin, D. A. Vuitton, Y. Zhang, and X. Lu, “Northwestern China: a place to learn more on oesophageal cancer. Part two: gene alterations and polymorphisms,” European Journal of Gastroenterology and Hepatology, vol. 23, no. 12, pp. 1087–1099, 2011. View at Publisher · View at Google Scholar · View at Scopus
  5. D. Baek, J. Villén, C. Shin, F. D. Camargo, S. P. Gygi, and D. P. Bartel, “The impact of microRNAs on protein output,” Nature, vol. 455, no. 7209, pp. 64–71, 2008. View at Publisher · View at Google Scholar · View at Scopus
  6. M. Selbach, B. Schwanhäusser, N. Thierfelder, Z. Fang, R. Khanin, and N. Rajewsky, “Widespread changes in protein synthesis induced by microRNAs,” Nature, vol. 455, no. 7209, pp. 58–63, 2008. View at Publisher · View at Google Scholar · View at Scopus
  7. Y. Ni, L. Meng, L. Wang et al., “MicroRNA-143 functions as a tumor suppressor in human esophageal squamous cell carcinoma,” Gene, vol. 517, no. 2, pp. 197–204, 2013. View at Publisher · View at Google Scholar · View at Scopus
  8. A. Esquela-Kerscher and F. J. Slack, “Oncomirs-microRNAs with a role in cancer,” Nature Reviews Cancer, vol. 6, no. 4, pp. 259–269, 2006. View at Publisher · View at Google Scholar · View at Scopus
  9. M. Yang, R. Liu, J. Sheng et al., “Differential expression profiles of microRNAs as potential biomarkers for the early diagnosis of esophageal squamous cell carcinoma,” Oncology Reports, vol. 29, no. 1, pp. 169–176, 2013. View at Publisher · View at Google Scholar · View at Scopus
  10. K. Matsushima, H. Isomoto, N. Yamaguchi et al., “MiRNA-205 modulates cellular invasion and migration via regulating zinc finger E-box binding homeobox 2 expression in esophageal squamous cell carcinoma cells,” Journal of Translational Medicine, vol. 9, article 30, 2011. View at Publisher · View at Google Scholar · View at Scopus
  11. J. A. Chan, A. M. Krichevsky, and K. S. Kosik, “MicroRNA-21 is an antiapoptotic factor in human glioblastoma cells,” Cancer Research, vol. 65, no. 14, pp. 6029–6033, 2005. View at Publisher · View at Google Scholar · View at Scopus
  12. L. F. Xu, Z. P. Wu, Y. Chen, Q. S. Zhu, S. Hamidi, and R. Navab, “MicroRNA-21 (miR-21) regulates cellular proliferation, invasion, migration, and apoptosis by targeting PTEN, RECK and Bcl-2 in lung squamous carcinoma, Gejiu City, China,” PLoS ONE, vol. 9, no. 8, Article ID e103698, 2014. View at Publisher · View at Google Scholar
  13. L. Lv, F. Huang, H. Mao et al., “MicroRNA-21 is overexpressed in renal cell carcinoma,” International Journal of Biological Markers, vol. 28, no. 2, pp. 201–207, 2013. View at Publisher · View at Google Scholar · View at Scopus
  14. Y. Hiyoshi, H. Kamohara, R. Karashima et al., “MicroRNA-21 regulates the proliferation and invasion in esophageal squamous cell carcinoma,” Clinical Cancer Research, vol. 15, no. 6, pp. 1915–1922, 2009. View at Publisher · View at Google Scholar · View at Scopus
  15. X. Li, K. Huang, and J. Yu, “Inhibition of microRNA-21 upregulates the expression of programmed cell death 4 and phosphatase tensin homologue in the A431 squamous cell carcinoma cell line,” Oncology Letters, vol. 8, no. 1, pp. 203–207, 2014. View at Publisher · View at Google Scholar · View at Scopus
  16. W. Ren, X. Wang, L. Gao et al., “miR-21 modulates chemosensitivity of tongue squamous cell carcinoma cells to cisplatin by targeting PDCD4,” Molecular and Cellular Biochemistry, vol. 390, no. 1-2, pp. 253–262, 2014. View at Publisher · View at Google Scholar · View at Scopus
  17. I. A. Asangani, S. A. K. Rasheed, D. A. Nikolova et al., “MicroRNA-21 (miR-21) post-transcriptionally downregulates tumor suppressor Pdcd4 and stimulates invasion, intravasation and metastasis in colorectal cancer,” Oncogene, vol. 27, no. 15, pp. 2128–2136, 2008. View at Publisher · View at Google Scholar · View at Scopus
  18. Z. Cao, J. H. Yoon, S. W. Nam, J. Y. Lee, and W. S. Park, “PDCD4 expression inversely correlated with miR-21 levels in gastric cancers,” Journal of Cancer Research and Clinical Oncology, vol. 138, no. 4, pp. 611–619, 2012. View at Publisher · View at Google Scholar · View at Scopus