Fluvastatin Upregulates the α_1C Subunit of CaV1.2 Channel Expression in Vascular Smooth Muscle Cells via RhoA and ERK/p38 MAPK Pathways

Figure 4

Effects of MAPK or ROCK inhibition on LTCC expression after PDGF stimulation in VSMCs. LTCC protein expression was evaluated by western blot analysis. Data was described as means ± SEM from three experiments performed in triplicate. versus blank control and versus PDGF stimulated cells. MAPK: mitogen activated protein kinase; ROCK: Rho associated protein kinase; LTCC: L-type calcium channel subunit; Flu: fluvastatin; and PDGF: platelet derived growth factor.