RBP4 Gene Variants Are Associated with Insulin Resistance in Women with Previous Gestational Diabetes

Table 3

Association between SNPs and clinical features in two groups at postpartum.

rs3758539

rs34571439

rs116736522

GDM

Healthy controls

GDM

Healthy controls

GDM

Healthy controls

G/G

A/G and A/A

G/G

A/G and A/A

A/A

A/C and C/C

A/A

A/C and C/C

G/G

G/C and C/C

G/G

G/C and C/C

BMI (kg/m^2)

30.3±3.9

29.0±5.2

27.2±11.0

23.1±1.9

30.5±3.9

28.6±5.2

27.5±11.6

23.8±2.0

30.3±4.1

27.6±3.7

26.5±10.7

28.3±6.2

Glucose (mmol/L)

5.93±1.9

6.5±2.7

4.3±0.5

4.2±0.3

6.0±1.9

6.1±2.3

4.3±0.05

4.2±0.4

6.0±2.05

5.9±1.2

4.3±0.5

4.1±0.3

Insulin (pmol/L)

64.8±80.4^∗†

102.0±77.4

36.6±44.4

28.8±7.2

64.2±82.2^∗†

98.4±75.0

39.6±46.2

22.8±16.2

74.4±84.0

55.2±34.2

33.6±40.2

60.6±60.0

RBP4 (𝜇g/mL)

4.9±1.0

4.4±0.9

4.3±1.0

4.6±0.7

4.9±1.0

4.4±1.0

4.3±1.0

4.4±0.8

4.9±1.0

4.2±0.4

4.2±0.9^∗

4.9±0.3

HOMA-IR

2.7±3.5^∗†

5.8±7.2

1.2±1.6

0.9±0.2

2.7±3.5^∗†

5.4±7.0

1.3±1.7

0.7±0.5

3.5±5.0

2.5±1.5

1.1±1.5

1.7±1.6

Cholesterol (mmol/L)

6.1±1.2

6.0±1.5

5.5±1.3^∗

6.4±0.92

6.1±1.2

5.9±1.6

5.5±1.3

6.0±1.1

6.1±1.3

5.3±1.2

5.5±1.3^∗

7.0±1.1

Triglycerides (mmol/L)

2.3±1.1

2.5±1.2

1.8±1.1

1.4±0.3

2.2±1.0

2.6±1.1

1.9±1.1

1.3±0.5

2.3±1.1

2.3±1.2

1.7±1.0

2.4±1.3

Data are mean ± SD.
^∗𝑃<0.05.
^†𝑃<0.05 adjusted for age and BMI.