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Disease Markers
Volume 2014, Article ID 269362, 5 pages
Research Article

New Markers: Urine Xanthine Oxidase and Myeloperoxidase in the Early Detection of Urinary Tract Infection

1Yasamlab Laboratory, Department of Clinical Microbiology, Guzelevler Mahallesi Papatya Sokak Mobilyacılar Sitesi 6, Blok No. 13, Yuregir, 01220 Adana, Turkey
2Sutcu Imam University, Faculty of Medicine, Department of Biochemistry, 46050, Kahramanmaras, Turkey
3Cukurova University, Faculty of Medicine, Department of Microbiology, 01050, Adana, Turkey

Received 18 June 2013; Accepted 20 November 2013; Published 29 January 2014

Academic Editor: Francisco Blanco-Vaca

Copyright © 2014 Pınar Ciragil et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Objectives. The aim of this study was to evaluate if xanthine oxidase and myeloperoxidase levels quantitation method may alternate routine culture method, which takes more time in the diagnosis of urinary tract infections. Material and Methods. Five hundred and forty-nine outpatients who had admitted to Clinic Microbiology Laboratory were included in the study. The microorganisms were identified by using VITEK System. The urine specimens that were negative from the quantitative urine culture were used as controls. The activities of MPO and XO in spot urine were measured by spectrophotometric method. Results. Through the urine cultures, 167 bacteria were isolated from 163 urine specimens; 386 cultures yielded no bacterial growth. E. coli was the most frequent pathogen. In infection with E. coli both XO and MPO levels were increased the most. The sensitivity, specificity, positive predictive value, and negative predictive value for XO were 100%, 100%, 100%, and 100%, respectively. These values for MPO were 87%, 100%, 100%, and 94%, respectively. Conclusion. These data obtained suggest that urine XO and MPO levels may be new markers in the early detection of UTI.