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Disease Markers
Volume 2014, Article ID 308976, 10 pages
Review Article

Annexin A2: Its Molecular Regulation and Cellular Expression in Cancer Development

Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, 1 University Road, Tainan 701, Taiwan

Received 29 June 2013; Revised 31 October 2013; Accepted 1 November 2013; Published 23 January 2014

Academic Editor: Robert Pichler

Copyright © 2014 Chi-Yun Wang and Chiou-Feng Lin. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Annexin A2 (ANXA2) orchestrates multiple biologic processes and clinical associations, especially in cancer progression. The structure of ANXA2 affects its cellular localization and function. However, posttranslational modification and protease-mediated N-terminal cleavage also play critical roles in regulating ANXA2. ANXA2 expression levels vary among different types of cancers. With some cancers, ANXA2 can be used for the detection and diagnosis of cancer and for monitoring cancer progression. ANXA2 is also required for drug-resistance. This review discusses the feasibility of ANXA2 which is active in cancer development and can be a therapeutic target in cancer management.