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Disease Markers
Volume 2014, Article ID 315843, 6 pages
http://dx.doi.org/10.1155/2014/315843
Research Article

Urinary N-Acetyl-beta-D-glucosaminidase as an Early Marker for Acute Kidney Injury in Full-Term Newborns with Neonatal Hyperbilirubinemia

1Clinical Laboratory, Children’s Hospital of Anhui Province, Hefei, Anhui 230000, China
2Department of Paediatrics, Children’s Hospital of Anhui Province, Hefei, Anhui 230000, China
3Department of Paediatrics, Third Xiangya Hospital of Central South University, Changsha, Hunan 410013, China
4Operation Center, Third Xiangya Hospital of Central South University, Changsha, Hunan 410013, China

Received 11 May 2014; Revised 5 June 2014; Accepted 10 June 2014; Published 24 June 2014

Academic Editor: Serge Masson

Copyright © 2014 Bangning Cheng et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Purpose. To investigate renal function estimated by markers in full-term newborns with hyperbilirubinemia. Methods. A total of 332 full-term newborns with hyperbilirubinemia and 60 healthy full-term newborns were enrolled. Total serum bilirubin, serum creatinine (Cr), serum blood urea nitrogen (BUN), serum cystatin C (Cys-C), urinary beta-2-microglobulin (β2MG) index, and urinary N-acetyl-beta-D-glucosaminidase (NAG) index were measured before and after treatment. All newborns were divided into three groups according to total serum bilirubin levels: group 1 (221-256), group 2 (256-342), and group 3 (>342). Results. The control group and group 1 did not differ significantly in regard to serum Cr, serum BUN, serum Cys-C, urinary β2MG index, and urinary NAG index. Urinary NAG index in group 2 was significantly higher than that in control group (). Between control group and group 3, serum Cys-C, urinary β2MG index, and urinary NAG index differed significantly. The significant positive correlation between total serum bilirubin and urinary NAG index was found in newborns when total serum bilirubin level was more than 272 μmol/L. Conclusions. High unconjugated bilirubin could result in acute kidney injury in full-term newborns. Urinary NAG might be the suitable marker for predicting acute kidney injury in full-term newborns with hyperbilirubinemia.