Research Article
The Role of TPA I/D and PAI-1 4G/5G Polymorphisms in Multiple Sclerosis
Table 2
Frequencies of TPA I/D and PAI-1 4G/5G genotypes and alleles in MS patients and controls and uncorrected ORs for MS susceptibility.
| |
Genotype/allele | Serbian cohort | BH cohort | Pooled samples* | MS patients
(%) | Controls
(%) | OR
(95% CI) | | MS patients
(%) | Controls
(%) | OR
(95% CI) | | MS patients
(%) | Controls
(%) | OR
(95% CI) | |
| | TPA I/D | | | | | | | | | | | | | | II | 117 (30.6) | 98 (30.8) | 0.99 (0.72–1.37) | 0.957 | 54 (31.8) | 42 (24.7) | 1.42 (0.88–2.28) | 0.149 | 277 (31.3) | 261 (30.5) | 1.04 (0.85–1.27) | 0.715 | | ID | 181 (47.4) | 134 (42.1) | 1.24 (0.92–1.67) | 0.165 | 74 (43.5) | 87 (51.2) | 0.73 (0.48–1.13) | 0.158 | 408 (46.1) | 367 (42.9) | 1.14 (0.94–1.38) | 0.176 | | DD | 84 (22.0) | 86 (27.1) | 0.76 (0.54–1.01) | 0.121 | 42 (24.7) | 41 (24.1) | 1.03 (0.63–1.70) | 0.899 | 200 (22.6) | 228 (26.6) | 0.80 (0.65–1.00) | 0.050 | | Total | 382 | 318 | | | 170 | 170 | | | 885 | 856 | | |
| | Allele I (%) | 415 (54.3) | 330 (51.9) | 1.10 (0.89–1.36) | 0.364 | 182 (53.5) | 171 (50.3) | 1.14 (0.84–1.54) | 0.399 | 962 (54.4) | 889 (52.0) | 1.10 (0.96–1.26) | 0.152 | | Allele D (%) | 349 (45.7) | 306 (48.1) | 0.91 (0.73–1.12) | 0.364 | 158 (46.5) | 169 (49.7) | 0.88 (0.65–1.19) | 0.399 | 808 (45.6) | 823 (48.0) | 0.91 (0.79–1.04) | 0.152 |
| | PAI 4G/5G | | | | | | | | | | | | | | 4G4G | 118 (30.9) | 88 (27.7) | 1.17 (0.84–1.62) | 0.353 | 41 (24.1) | 44 (25.9) | 0.91 (0.57–1.49) | 0.707 | 245 (27.7) | 241 (28.1) | 0.98 (0.79–1.20) | 0.827 | | 4G5G | 182 (47.6) | 182 (57.2) | 0.68 (0.50–0.92) | 0.012 | 97 (57.1) | 87 (51.2) | 1.27 (0.83–1.94) | 0.277 | 457 (51.6) | 469 (54.8) | 0.88 (0.73–1.06) | 0.188 | | 5G5G | 82 (21.5) | 48 (15.1) | 1.54 (1.04–2.28) | 0.032 | 32 (18.2) | 39 (22.9) | 0.78 (0.46–1.32) | 0.351 | 183 (20.7) | 146 (17.1) | 1.27 (0.97–1.61) | 0.054 | | Total | 382 | 318 | | | 170 | 170 | | | 885 | 856 | | |
| | Allele 4G (%) | 418 (54.7) | 358 (56.3) | 0.94 (0.76–1.16) | 0.554 | 179 (52.6) | 175 (51.5) | 1.05 (0.78–1.42) | 0.759 | 947 (53.5) | 951 (55.5) | 0.92 (0.80–1.05) | 0.225 | | Allele 5G (%) | 348 (45.3) | 278 (43.7) | 1.07 (0.86–1.32) | 0.554 | 161 (47.4) | 165 (48.5) | 0.95 (0.71–1.29) | 0.759 | 823 (46.5) | 761 (44.5) | 1.09 (0.95–1.24) | 0.225 |
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Subjects analyzed in the current study (Serbian and BH) and subjects analyzed previously (Croatian and Slovenian) [12].
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