MicroRNA Expression Profiling in PBMCs: A Potential Diagnostic Biomarker of Chronic Hepatitis C

Table 2

Up- and downexpressed microRNAs in PBMCs of CHC patients compared with the healthy donors.

MicroRNAs	Endogenous control
	RUN44		U6B
	RQ^*		RQ^*
Downregulated miRNAs
miR-330-3p	0.01		0
miR-371-3p	0.02		0
miR-501-5p	0.04		0
miR-636	0.04		0
miR-214	0.08		0
miR-886-3p	0.09		0
miR-548c-5p	0.11		0
miR-422a	0.12		0
miR-886-5p	0.24		0
miR-545	0.27		0
miR-326	0.29		0
miR-9	0.29		0
miR-579	0.38		0.01
miR-124	0.39		0.01
miR-627	0.42		0.01
miR-449b	0.5		—	—
miR-564	0.65		0
miR-222^*	—	—	0
miR-15^*	—	—	0
miR-16-1^*	—	—	0
Upregulated miRNAs
miR-7-1^*	5405.77	3.73	2.01	0.3
miR-126^*	2486.35	3.4	1.3	0.11
miR-199a-3p	814.45	2.91	10.77	1.03
miR-489	592.42	2.77	7.83	0.89
miR-194	484.64	2.69	6.41	0.81
miR-590-5p	397.96	2.6	5.26	0.72
let-7e	311.16	2.49	4.11	0.61
miR-15b	261.75	2.42	3.46	0.54
miR-19a	245.95	2.39	3.25	0.51
miR-19b	233.54	2.37	3.09	0.49
miR-376c	228.43	2.36	3.02	0.48
miR-324-5p	224.46	2.35	2.97	0.47
miR-374a	218.5	2.34	2.89	0.46
miR-27b	193.3	2.29	2.56	0.41
miR-452	182.34	2.26	2.41	0.38
miR-96	176.66	2.25	2.34	0.37
miR-210	171.29	2.23	2.26	0.35
miR-139-5b	155.02	2.19	2.05	0.31

PBMCs: peripheral blood mononuclear cells; CHC: chronic hepatitis C.
^*Real-time relative quantification (RQ) values.