MicroRNA Expression Profiling in PBMCs: A Potential Diagnostic Biomarker of Chronic Hepatitis C

Table 4

The association of the targets miRNAs expression levels and clinical factors (such as ALT, AST, and liver fibrosis) of the CHC patients.

Parameters	miR-193b	miR-199a-3p	miR-122	miR-16	miR-214	miR-222	miR-324-3p
ALT
<40 U/L	0.169 ± 0.838	777.105 ± 2178.070	0.003 ± 0.010	21.762 ± 69.405	18.220 ± 65.577	0.425 ± 0.954	7.771 ± 39.245
≧40 U/L	0.214 ± 1.464	1113.280 ± 497.265	0.001 ± 0.002	212.344 ± 504.989	54.410 ± 200.481	3.425 ± 11.770	26.781 ± 67.231
value	0.001	0.009	<0.0001	<0.0001	0.235	<0.0001	0.001
AST
<40 U/L	0.027 ± 0.005	426.223 ± 1115.870	0.003 ± 0.012	13.217 ± 40.283	17.412 ± 64.851	0.496 ± 1.135	11.157 ± 48.112
≧40 U/L	0.174 ± 1.297	882.580 ± 436.044	0.001 ± 0.003	168.314 ± 445.087	45.757 ± 177.139	2.631 ± 10.244	20.214 ± 58.935
value	<0.0001	<0.0001	<0.0001	<0.0001	0.760	<0.0001	0.001
Liver cirrhosis
No	0.228 ± 1.410	964.452 ± 454.544	0.017 ± 0.122	197.502 ± 490.549	150.749 ± 891.345	2.529 ± 5.821	45.846 ± 209.718
Yes	0.012 ± 0.029	1340.147 ± 440.160	0.001 ± 0.003	109.524 ± 243.190	40.417 ± 79.656	6.452 ± 19.406	34.221 ± 86.321
value	0.221	0.800	0.866	0.996	0.054	0.584	0.508

AST: aspartate aminotransferase; ALT: alanine aminotransferase.