MicroRNA Expression Profiling in PBMCs: A Potential Diagnostic Biomarker of Chronic Hepatitis C

Table 5

Multivariate logistic regression analysis of the risk of CHC.

Parameters	Favorable/unfavorable	OR	95% CI	value
Gender	Female/male	0.227	0.080–0.648	0.006
Age	Per year	1.182	1.1062013;1.262	<0.001
BMI	≧27/<27	2.090	0.394–11.074	0.386
Six target miRNAs	High/low	7.202	2.014–25.727	0.002

Six target miRNAs were including miR-16, miR-122, miR-193b, miR-199a-3p, miR-222, and miR-324-3p.
In CHC patients’ PBMC, the expression levels of miR-16, miR-122, miR-193b, miR-199a-3p, miR-222, and miR-324-3p were increased and miR-122 expression was decreased compared with healthy controls.