Severity of Hepatitis C Virus (Genotype-3) Infection Positively Correlates with Circulating MicroRNA-122 in Patients Sera
Figure 2
(a) Scattered plot diagram showing level of miR-122 expression in CHC patients and controls. The data are expressed as the mean ± SD from separate experiments performed in triplicates. Here, ΔCt value was normalized by U6 snRNA at log 10 scale which is shown at -axis. The median value of miR-122 level is significantly higher in patients than controls, 0.66 versus 0.29 (). (b) Receiver operating characteristic (ROC) curve for miR-122 in 25 chronic hepatitis C patients. The diagnostic value of miR-122 was assessed by discriminating CHC patients from healthy controls based on the ΔCt value. SE: sensitivity, SP: specificity, +PV: positive predictive value, and −PV: negative predictive value.
