Association of the Three Common SNPs of Cyclooxygenase-2 Gene (rs20417, rs689466, and rs5275) with the Susceptibility of Breast Cancer: An Updated Meta-Analysis Involving 34,590 Subjects

Table 1

Characteristics of the studies included in the meta-analysis.

First author	Year	Country	Ethnicity	Study design	Genotyping method	Source of control	Total sample size (case/control)	SNP number
Gao [20]	2014	China	Asian	CC	TaqMan	Hospital	465/799	1, 3
Fawzy [18]	2013	Egypt	African	CC	PCR-RFLP	Hospital	160/150	3
Brasky [19]	2011	USA	Caucasian	CC	TaqMan	Population	1077/1910	2, 3
Piranda [16]	2010	Brazil	Caucasian	CC	TaqMan	Population	318/273	1, 2, 3
Dossus [21]	2010	USA, Europe	Caucasian	CC	Illumina	Population	6292/8135	1, 2, 3
Abraham [22]	2009	EPIC	Caucasian	CC	TaqMan	Population	2200/2280	3
Gao [23]	2007	China	Asian	CC	PCR-RFLP	Hospital	601/643	1, 2, 3
Cox 1 [24]	2007	USA	Caucasian	CC	TaqMan	Population	1270/1762	1, 3
Cox 2 [24]	2007	USA	Caucasian	CC	TaqMan	Population	317/634	3
Cox 3 [24]	2007	USA	Caucasian	CC	TaqMan	Population	702/703	3
Vogel [25]	2007	Denmark	Caucasian	CC	TaqMan	Hospital	361/361	3
Langsenlehner [26]	2006	Austria	Caucasian	CC	TaqMan	Hospital	500/500	3
Shen [27]	2006	USA	Mixed	CC	PCR-RFLP	Population	1067/1110	1, 3

CC: case-control; PCR: polymerase chain reaction; RFLP: restriction fragment length polymorphism. EPIC: European Prospective Investigation of Cancer (a prospective study of diet and cancer being carried out in nine European countries). SNP: single-nucleotide polymorphisms; SNP number 1: −765G>C (rs20417); 2: −1195G>A (rs689466); 3: 8473T>C (rs5275).