Association of the Three Common SNPs of Cyclooxygenase-2 Gene (rs20417, rs689466, and rs5275) with the Susceptibility of Breast Cancer: An Updated Meta-Analysis Involving 34,590 Subjects

Table 2

COX-2 polymorphisms genotype distribution and allele frequency in cases and controls.

First author	Genotype ()								Allele frequency ()				MAF
	Case				Control				Case		Control
	Total	AA	AB	BB	Total	AA	AB	BB	A	B	A	B
rs20417
Gao 2014 [20]	465	394	67	4	799	719	76	4	855	75	1514	84	0.08
Piranda 2010 [16]	308	157	127	24	264	129	117	18	441	175	375	153	0.28
Dossus 2010 [21]	6254	4394	1646	214	8092	5694	2166	232	10434	2074	13554	2630	0.17
Gao 2007 [23]	601	526	73	2	643	582	59	2	1125	77	1223	63	0.06
Cox 1 2007 [24]	1243	865	336	42	1715	1185	485	45	2066	420	2855	575	0.17
Shen 2006 [27]	1067	670	387		1105	691	414		—	—	—	—	—
rs689466
Brasky 2011 [19]	1077	660	271	34	1910	1199	471	54	1591	339	2869	579	0.18
Piranda 2010 [16]	289	224	62	3	245	190	51	3	510	68	431	57	0.12
Dossus 2010 [21]	6247	4020	1928	299	8115	5143	2562	410	9968	2526	12848	3382	0.20
Gao 2007 [23]	601	121	305	175	643	150	327	166	547	655	627	659	0.54
rs5275
Gao 2014 [20]	465	299	132	34	799	515	244	40	730	200	1274	324	0.22
Fawzy 2013 [18]	160	53	71	36	150	69	67	14	177	143	205	95	0.45
Brasky 2011 [19]	1077	432	447	108	1910	732	782	226	1311	663	2246	1234	0.31
Piranda 2010 [16]	294	125	149	20	244	120	99	25	399	189	339	149	0.32
Dossus 2010 [21]	6133	2697	2664	772	7946	3512	3501	933	8058	4208	10525	5367	0.34
Abraham 2009 [22]	2172	927	985	260	2265	996	1010	259	2839	1505	3002	1528	0.35
Gao 2007 [23]	601	404	179	18	643	429	194	20	987	215	1052	234	0.18
Cox 1 2007 [24]	1249	541	567	141	1720	699	808	213	1649	849	2206	1234	0.34
Cox 2 2007 [24]	301	140	131	30	610	270	259	81	411	191	799	421	0.32
Cox 3 2007 [24]	644	281	296	67	651	278	294	79	858	430	850	452	0.33
Vogel 2007 [25]	361	167	150	44	361	155	165	41	484	238	475	247	0.33
Langsenlehner 2006 [26]	500	214	224	62	500	234	232	33	652	348	700	298	0.35
Shen 2006 [27]	1060	475	585		1102	467	635		—	—	—	—	—

A represents the major allele; B represents the minor allele. MAF: minor allele frequencies.