Variability of the Transferrin Receptor 2 Gene in AMD
Table 5
Distribution of genotypes, frequency of alleles of the c.−258+123T>C polymorphism of the TFR2 gene, and odds ratios (OR) with 95% confidence intervals (95% CI) in age-related macular degeneration (AMD) and controls with respect to body mass index (BMI) (<26; 26–30; >30).
Genotype/allele c. −258+123T>C
BMI <26
Control (63) Number (%)
AMD (153) Number (%)
OR1) (95% CI)
TT
22 (0.35)
55 (0.36)
1.05 (0.57–1.96)
0.870
TC
24 (0.38)
74 (0.48)
1.57 (0.85–2.88)
0.149
CC
17 (027)
24 (0.16)
0.48 (0.23–0.98)↓
0.044
T
68 (0.54)
184 (0.60)
1.29 (0.86–1.95)
0.224
C
58 (0.46)
122 (0.40)
0.77 (0.51–1.17)
0.224
Genotype/allele c. −258+123T>C
BMI 26–30
Control (43) Number (%)
AMD (144) Number (%)
OR1) (95% CI)
TT
14 (0.33)
50 (0.35)
1.11 (0.53–2.33)
0.790
TC
19 (0.44)
63 (0.44)
1.03 (0.51–2.09)
0.937
CC
10 (0.23)
31 (0.22)
0.84 (0.36–1.9)
0.685
T
47 (0.55)
163 (0.57)
1.1 (0.69–1.77)
0.690
C
39 (0.45)
125 (0.43)
0.91 (0.57–1.46)
0.690
Genotype/allele c. −258+123T>C
BMI >30
Control (171) Number (%)
AMD (77) Number (%)
OR1) (95% CI)
TT
60 (0.35)
21 (0.27)
0.69 (0.3–1.58)
0.373
TC
75 (0.43)
39 (0.51)
1.16 (0.53–2.55)
0.710
CC
38 (0.22)
17 (0.22)
1.32 (0.49–3.53)
0.580
T
193 (0.56)
81 (0.53)
0.78 (0.45–1.35)
0.374
C
149 (0.44)
73 (0.47)
1.28 (0.74–2.23)
0.374
Adjusted for age and sex; test; data in boldface are statistically significant.
