Variability of the Transferrin Receptor 2 Gene in AMD

Table 6

Distribution of genotypes, frequency of alleles of the c.258+123T>C polymorphism of the TFR2 gene, and odds ratios (OR) with 95% confidence intervals (95% CI) in age-related macular degeneration (AMD) and controls in two age groups (<72 and ≥72).

Genotype/allele; c.−258+123T>C	Age
	<72				≥72
	Control; (𝑁=87)	AMD; (𝑁=227)	OR^1) (95% CI)	𝑃^2)	Control; (𝑁=83)	AMD; (𝑁=247)	OR^1) (95% CI)	𝑃^2)
	𝑁 (%)	𝑁 (%)			𝑁 (%)	𝑁 (%)
TT	38 (0.44)	76 (0.33)	0.33 (0.15–0.73)↓	0.006	21 (0.25)	80 (0.32)	1.79 (0.73–4.39)	0.203
TC	33 (0.38)	101 (0.44)	2.57 (1.11–5.96)↑	0.028	40 (0.48)	123 (0.50)	0.94 (0.43–2.09)	0.887
CC	16 (0.18)	50 (0.22)	1.41 (0.55–3.64)	—	22 (0.27)	44 (0.18)	0.54 (0.21–1.41)	0.209
T	109 (0.63)	253 (0.56)	0.56 (0.33–0.95)↓	0.031	82 (0.49)	283 (0.57)	1.57 (0.89–2.78)	0.123
C	65 (0.37)	201 (0.44)	1.79 (1.05–3.03)↑	0.031	84 (0.51)	211 (0.43)	0.64 (0.36–1.13)	0.123

1)Odds ratio adjusted for age and living environment; ²⁾𝜒² test; data in boldface are statistically significant.