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Disease Markers
Volume 2014, Article ID 509821, 8 pages
http://dx.doi.org/10.1155/2014/509821
Research Article

Comparison of Different Blood Collection, Sample Matrix, and Immunoassay Methods in a Prenatal Screening Setting

1Centre for Health Protection (GZB), National Institute for Public Health and the Environment (RIVM), P.O. Box 1, 3720 BA Bilthoven, The Netherlands
2Centre for Infectious Diseases Research, Diagnostics and Screening (IDS), National Institute for Public Health and the Environment (RIVM), P.O. Box 1, 3720 BA Bilthoven, The Netherlands
3Department of Obstetrics, Wilhelmina Children’s Hospital, University Medical Centre Utrecht (UMCU), P.O. Box 85090, 3508 AB Utrecht, The Netherlands

Received 26 May 2014; Accepted 4 July 2014; Published 15 July 2014

Academic Editor: Donald H. Chace

Copyright © 2014 Jeroen L. A. Pennings et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Supplementary figure 1: Comparison of blood collection (vein and finger) and sample matrix (serum and DBS) values for PAPP-A, using AutoDELFIA.

Supplementary figure 2: Comparison of blood collection (vein and finger) and sample matrix (serum and DBS) values for fβ-hCG, using AutoDELFIA.

Supplementary figure 3: Effects of blood collection and sample matrix using an antibody array platform. Finger serum versus vein serum for PAPP-A (A) and fβ- hCG (B); finger DBS versus finger serum for PAPP-A (C) and fβ-hCG (D).

  1. Supplementary Materials