Absence of Correlation between IL-28B Gene Polymorphisms and the Clinical Presentation of Chronic Hepatitis B in an Amazon Brazilian Population
Table 2
Association between the clinical and laboratory variables and the IL-28B gene polymorphisms in chronically infected HBV patients.
Variables
Genotypes of polymorphism rs12979860
P
Genotypes of polymorphism rs8099917
P
CC
CT
TT
GG
GT
TT
Clinical presentation (%)
0.3654a
0.4820a
Inactive carrier
07 (33.3)
14 (51.9)
05 (29.4)
02 (40.0)
07 (30.4)
17 (46.0)
Chronic hepatitis without cirrhosis
09 (42.9)
08 (29.6)
10 (58.8)
03 (60.0)
11 (47.8)
13 (35.1)
Chronic hepatitis with cirrhosis
05 (23.8)
05 (18.5)
02 (11.8)
—
05 (21.5)
07 (18.9)
Total
21
27
17
05
23
37
Laboratory
Hemoglobin (12–18 g/dL)
0.2729b
0.0994b
Leukocytes (4000–10000 cells/mm³)
0.1520b
0.8964b
Platelets (150000–400000 cells/mm³)
0.4584b
0.5967b
AST (16–40 U/mL)
0.3683b
0.4418b
ALT (4–32 U/mL)
0.6250b
0.8702b
GGT (4–366 U/mL)
0.8543b
0.4579b
Viral load (U/mL)
0.8047c
0.4677c
HBeAg (%)
Positive
03 (14.3)
05 (19.2)
04 (25.0)
0.7276a
01 (20.0)
06 (27.3)
05 (13.9)
0.4991a
Negative
18 (85.7)
21 80.8)
12 (75.0)
04 (80.0)
16 (71.7)
31 (86.1)
Total
21
26
16
05
22
36
Notes: = arithmetic mean; σ = standard deviation
a test with Williams’ correction.
bANOVA
cKruskal-Wallis test AST: aspartate aminotransferase ALT: alanine aminotransferase GGT: gamma glutamyl transferase HBeAg: e antigen of the hepatitis B virus