K-ras Mutational Status in Cytohistological Tissue as a Molecular Marker for the Diagnosis of Pancreatic Cancer: A Systematic Review and Meta-Analysis

Table 2

Summary of the diagnostic accuracy of K-ras mutation level in different materials in the same patient group using MetaDisc (Version 1.4).

	FNA	ERCP	Surgery
SEN	79 (95% CI: 72–85%)	76% (95% CI: 72–79%)	80% (95% CI: 74–85%)
SPE	94 (95% CI: 84–98%)	92% (95% CI: 89–95%)	79% (95% CI: 73–85%)
PLR	7.87 (95% CI: 2.95–20.97)	6.83 (95% CI: 3.40–13.73)	3.64 (2.42–5.47)
NLR	0.24 (95% CI: 0.18–0.32)	0.34 (95% CI: 0.19–0.58)	0.26 (0.20–0.36)
DOR	34.26 (95% CI: 10.01–117.2)	23.92 (95% CI: 8.20–69.77)	14.88 (95% CI: 7.51–29.47)
AUC	0.6957	0.9541	0.8540

SEN: sensitivity; SPE: specificity; PLR: positive likelihood ratio; NLR: negative likelihood ratio; DOR: diagnostic odds ratio; and AUC: area under curve.