CLCA2 as a Novel Immunohistochemical Marker for Differential Diagnosis of Squamous Cell Carcinoma from Adenocarcinoma of the Lung

Table 1

Genes specifically expressed in squamous cell carcinoma of the lung.

Gene^a		Median expression value^b
Symbol	Description	Squamous cell carcinoma	Adenocarcinoma
KRT5	Keratin 5	100708.3884	40.18975
KRT6A	Keratin 6A	72788.57475	62.8728
PKP1	Plakophilin 1 (ectodermal dysplasia/skin fragility syndrome)	17091.659	97.2654
TP63	Tumor protein P63	9662.86635	69.23865
KRT6B	Keratin 6B	9498.8982	11.0179
CALML3	Calmodulin-like 3	6967.225	1.4188
DSG3	Desmoglein 3	6477.94655	1.12715
DSC3	Desmocollin 3	6416.14155	9.26815
KRT16	Keratin 16	5794.0321	49.5683
CLCA2	Chloride channel accessory 2	4860.0234	5.2242
KRT6C	Keratin 6C	4570.2383	5.23245
NTRK2	Neurotrophic tyrosine kinase, receptor, type 2	3944.6804	44.23865
SERPINB5	Serpin peptidase inhibitor, clade B (ovalbumin), member 5	3622.93785	22.98405
KRT13	Keratin 13	3557.4447	5.47095
GPX2	Glutathione peroxidase 2 (gastrointestinal)	3533.0995	99.7255
KRT14	Keratin 14	3094.8684	5.4587
FAT2	FAT atypical cadherin 2	2831.3711	18.2264
UGT1A6	UDP glucuronosyltransferase 1 family, polypeptide A6	2363.18645	17.0277
ANXA8	Annexin A8	2293.52705	38.38905
PTPRZ1	Protein tyrosine phosphatase, receptor-type, Z polypeptide	1949.045	28.1362
AKR1B10	Aldo-keto reductase family 1, member B10 (aldose reductase)	1708.73775	26.0211
PTHLH	Parathyroid hormone-like hormone	1686.3337	38.97765
BMP7	Bone morphogenetic protein 7	1682.00915	40.95445
GBP6	Guanylate binding protein family, member 6	1522.3459	16.8889

All the genes conforming to the following two conditions are listed: () median expression value of the gene ≥1500 in squamous cell carcinoma and () median expression value of the gene ≤100 in adenocarcinoma.
^bThe RSEM value is used to show the expression level.