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Disease Markers
Volume 2014 (2014), Article ID 628476, 7 pages
http://dx.doi.org/10.1155/2014/628476
Clinical Study

Different Profile of Serum Leptin between Early Onset and Late Onset Preeclampsia

1Cellular and Molecular Research Center, Zahedan University of Medical Sciences, Zahedan 9816743175, Iran
2Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan 9816743175, Iran
3Department of Pharmacology, School of Medicine, Zahedan University of Medical Sciences, Zahedan 9816743175, Iran
4Department of Medical Genetics, Faculty of Medical Sciences, Tarbiat Modares University, Tehran 14115-111, Iran
5Department of Obstetrics and Gynecology, School of Medicine, Zahedan University of Medical Sciences, Zahedan 9816743175, Iran
6Department of Biostatistics and Epidemiology, School of Public Health, Zahedan University of Medical Sciences, Zahedan 9816743175, Iran
7Pregnancy Health Research Center, Zahedan University of Medical Sciences, Zahedan 9816743175, Iran

Received 30 June 2013; Revised 13 October 2013; Accepted 6 November 2013; Published 23 January 2014

Academic Editor: Irene Rebelo

Copyright © 2014 Saeedeh Salimi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Aim. This study was designed to clarify the role of leptin and adiponectin in preeclampsia (PE) pathogenesis and different subtypes of preeclampsia. Method. This case control study was performed in 45 PE patients and 45 healthy controls matched for age, BMI, and ethnicity. Serum leptin and adiponectin levels were determined by enzyme linked immunosorbent assay (ELISA). Results. Maternal serum leptin and adiponectin were significantly higher in PE women than controls. Serum leptin was elevated in early onset preeclampsia (EOPE) and late onset preeclampsia (LOPE) compared to controls. Among PE patients, serum leptin was higher in EOPE than LOPE women. However, serum adiponectin was not different between EOPE and LOPE women. The serum leptin was significantly higher in severe PE than mild PE. The serum adiponectin was significantly elevated in severe PE compared to controls. Significant positive correlation was observed between leptin and adiponectin and also between leptin and BMI in controls. Moreover significant positive correlation was observed between adiponectin and BMI in PE patients and controls. Conclusion. The present study showed that serum leptin level may play a significant role as a biomarker to differentiate early and late onset PE and also its relation to BMI and severity of disease.