Mass Spectrometric Screening of Ovarian Cancer with Serum Glycans

Table 4

Representative sensitivities and specificities obtained from the training set.

Sensitivity	90%	85%	80%
Specificity	70%	80%	83%
CA-125 sensitivity	74% (cut-off: 35 U/mL)

Note. Biomarkers used in this classification were denoted in Table 3. Cut-off values of each biomarker were determined according to the standard sensitivity 70%. To combine multiple biomarkers for the screening, a classification score was calculated on the basis of the cut-off values and weighting factors. By varying the thresholds for the classification score, multiple pairs of sensitivity and specificity were acquired from the training set. Sensitivity of CA-125 level was calculated with 35 U/mL as a cut-off value.