Matrix Metalloproteinase-9: Its Interplay with Angiogenic Factors in Inflammatory Bowel Diseases

Table 4

Comparison of diagnostic performance of MMP-9 and CRP (a) in distinguishing CD from controls, (b) in distinguishing UC from controls, and (c) in distinguishing active UC from active CD.

(a)

Marker	Cut-off; value	Sensitivity	Specificity	+LR	−LR	Youden; index
MMP-9	3.22 ng/mL	53.1%	77.8%	2.39	0.6	0.309
CRP	11.4 mg/L	66.7%	100%		0.33	0.667

(b)

Marker	Cut-off; value	Sensitivity	Specificity	+LR	−LR	Youden; index
MMP-9	4.48 ng/mL	54.1%	85.2%	3.65	0.54	0.393
CRP	11.4 mg/L	60%	100%		0.4	0.600

(c)

Marker	Cut-off; value	Sensitivity	Specificity	+LR	−LR	Youden; index
MMP-9	9.35 ng/mL	54.0%	79.0%	2.57	0.58	0.330
CRP	53.78 mg/L	54.5%	61.6%	1.4	0.74	0.157