Diagnostic and Prognostic Role of Preoperative Circulating CA 15-3, CA 125, and Beta-2 Microglobulin in Renal Cell Carcinoma

Table 3

Comparisons of the biomarkers median values between patients with or without lymph node metastases (a) and with or without visceral metastases (b).

(a)   

	LN metastases				𝑃 value
	N0		N+
	Median	95% CI	Median	95% CI
CA 15-3 (U/mL)	20.79	19.71–22.30	47.27	31.15–67.73	<0.0001
CA 125 (U/mL)	10.36	9.48–11.56	17.60	9.05–104.90	0.001
β-2 m (mg/L)	2.00	1.90–2.10	2.70	1.80–5.90	0.002

(b)  

	Visceral metastases				𝑃 value
	M0		M+
	Median	95% CI	Median	95% CI
CA 15-3 (U/mL)	20.22	18.72–21.93	32.23	27.05–52.35	<0.0001
CA 125 (U/mL)	9.63	8.33–11.00	22.15	10.80–94.00	<0.0001
β-2 m (mg/L)	1.85	1.78–2.00	2.30	1.93–2.60	0.01