Study of Leptin and Adiponectin as Disease Markers in Subjects with Obstructive Sleep Apnea
Table 2
Metabolic characteristics of the study subjects grouped by polysomnographic diagnosis of OSA and OSA severity. Results are mean (standard deviation).
No
Mild
Moderate
Severe
Adiponectin (ug/mL)
14.70 (13.01)
10.53 (7.41)
10.64 (8.36)
8.87 (7.41)*
Leptin (ug/mL)
70.60 (64.80)
90.90 (86.0)
112.00 (78.60)
52.40 (47.40)
Leptin : adiponectin ratio
7.71 (6.64)
12.80 (15.41)
17.82 (18.24)
8.2 (8.81)
FBG (mmol/L)
6.34 (2.08)
6.27 (1.95)
9.99 (3.66)
8.17 (3.83)
Insulin (mIU/mL)
18.65 (13.51)
20.13 (23.55)
18.67 (13.09)
16.38 (11.05)
HOMA-IR
5.65 (3.98)
5.76 (6.52)
7.66 (6.36)
7.30 (4.54)
%
144.47 (121.38)
118.03 (89.75)
114.94 (30.69)
113.07 (76.51)*
%
61.46 (53.44)
73.83 (51.21)
53.37 (23.79)
42.40 (21.51)
Total cholesterol (mmol/L)
4.30 (1.19)
4.50 (1.02)
4.84 (1.15)
5.07 (1.37)
HDL-C (mmol/L)
1.04 (0.33)
1.08 (0.39)
1.03 (0.39)
0.96 (0.29)
L-CDL (mmol/L)
2.62 (1.04)
2.80 (0.98)
2.90 (0.93)
3.35 (1.22)*
TG (mmol/L)
1.48 (0.77)
1.53 (0.92)
1.77 (1.15)
1.72 (0.85)*
for trend <0.05. FBG: fasting blood glucose, HOMA-IR: homeostasis model assessment of insulin resistance, %: beta cell function, %: insulin sensitivity, HDL-C: high density lipoprotein cholesterol, LDL-C: low density lipoprotein cholesterol, and TG: triglycerides.
