A Disease Modification Effect of APOE E4 on the Association between Urinary Albumin Excretion and Cognition in Korean Adults
Table 3
Adjusted mean (±SE) scores of K-mMMSE and cognitive domains according to categories of UACR in APOE E4 noncarriers.
K-mMMSE and cognitive domain scores according to UACR (mg/g)
for overall
for linear
Partial eta-squared, %
<15.0
15.0–29.9
30.0–299.9
≥300.0
difference
trend
Number
4147
2169
1988
188
Global
K-mMMSE (100)
78.7 ± 0.2
77.6 ± 0.3
76.9 ± 0.3
74.9 ± 0.9
<0.001
<0.001
0.6
Domains
Attention (7)
3.8 ± 0.0
3.7 ± 0.0
3.6 ± 0.0
3.3 ± 0.1
<0.001
<0.001
0.3
Memory (26)
20.9 ± 0.1
20.6 ± 0.1
20.6 ± 0.1
19.9 ± 0.3
0.005
0.003
0.2
Orientation (20)
18.6 ± 0.0
18.5 ± 0.1
18.2 ± 0.1
18.1 ± 0.2
0.003
<0.001
0.3
Visuospatial (10)
8.2 ± 0.0
8.1 ± 0.0
8.0 ± 0.1
7.9 ± 0.2
0.053
0.006
0.1
Language (18)
15.2 ± 0.0
15.1 ± 0.1
14.9 ± 0.1
14.6 ± 0.2
<0.001
<0.001
0.3
Frontoexecutive (19)
11.9 ± 0.1
11.6 ± 0.1
11.5 ± 0.1
11.1 ± 0.3
<0.001
<0.001
0.5
Data are expressed as mean ± standard error. The numbers in the brackets following domain names represent the total (maximum) score. Adjusted for age, sex, educational attainments, smoking status, alcohol use, BMI, eGFR, hypertension, type 2 diabetes, hyperlipidemia, and CES-DK.
