Association of Tagging SNPs in the MTHFR Gene with Risk of Type 2 Diabetes Mellitus and Serum Homocysteine Levels in a Chinese Population

Table 3

Association of haplotypes in the MTHFR gene with risk of T2DM.

Haplotype*	Cases, %	Controls, %	OR^† (95% CI)	OR (95% CI)^‡
CTTTGA	34.9	32.2	1.00	1.00
CTCCGA	26.9	35.3	0.73 (0.60–0.88)	0.71 (0.58–0.87)
ATTCGC	17.3	12.5	1.22 (0.95–1.56)	1.20 (0.92–1.55)
ACTCAC	8.6	8.2	0.92 (0.67–1.25)	0.93 (0.67–1.29)
CTTCGA	6.7	8.8	0.79 (0.57–1.10)	0.80 (0.56–1.13)

In the order rs12121543, rs13306553, rs9651118, rs1801133, rs2274976, and rs1801131.
^†Adjusted for age. ^‡Adjusted for age, sex, BMI, and hypertension.