STAT4 Gene Polymorphisms Are Associated with Susceptibility and ANA Status in Primary Biliary Cirrhosis

Table 2

IL12A, IL12RB, and STAT4 SNPs in PBC patients and healthy subjects.

Gene	db SNP	Allele	GWAS cohort	Replication cohort	Combined cohort
		minor/major	patients (%)	patients (%)	patients (%)	Controls (%)	P	OR	95% CI
			(𝑛=302)	(𝑛=93)	(𝑛=395)	(𝑛=458)
IL12A	rs574808	C/T	17.2	18.3	17.5	18.1	0.75
IL12RB	rs3790567	A/G	26.8	22.0	25.7	22.9	0.18
STAT4	rs7574865	T/G	40.6	46.8	41.9	33.5	4.0×10^−4	1.43	1.17–1.74

IL12: interleukin 12; STAT4: signal transducer activator transcription 4; PBC: primary biliary cirrhosis; SNP: single nucleotide polymorphism; OR: odds ratio; CI: confidence interval.