STAT4 Gene Polymorphisms Are Associated with Susceptibility and ANA Status in Primary Biliary Cirrhosis

Table 3

STAT4 SNPs in PBC patients and healthy subjects.

db SNP	Allele minor/major	Patients (%) (𝑛=395)	Controls (%) (𝑛=458)	P	𝑃𝑐	OR	95% CI
rs10168266	A/G	34.5	28.7	9.4×10^−3	0.038	1.31	1.07–1.61
rs7594501	A/G	12.7	16.7	0.021
rs16833239	T/C	13.0	16.4	0.046
rs11889341	T/C	39.1	31.7	1.2×10^−3	9.6×10^−3	1.39	1.14–1.69
rs7574865	T/G	41.9	33.5	4.0×10^−4	3.2×10^−3	1.43	1.17–1.74
rs8179673	G/A	42.1	33.5	2.0×10^−4	1.6×10^−3	1.44	1.19–1.75
rs10181656	G/C	43.3	33.7	4.2×10^−5	3.4×10^−4	1.50	1.24–1.83
rs6752770	G/A	15.0	17.8	0.120

STAT4: signal transducer activator transcription 4; PBC: primary biliary cirrhosis; SNP: single nucleotide polymorphism; OR: odds ratio; 𝑃_𝑐: corrected P value; CI: confidence interval.