STAT4 Gene Polymorphisms Are Associated with Susceptibility and ANA Status in Primary Biliary Cirrhosis

Table 4

STAT4 haplotypes in PBC patients and healthy subjects.

Block	Haplotype		SNPs		Patients (%)	Controls (%)	P	OR	95% CI
					(𝑛^∗=790)	(𝑛^∗=916)
A		rs7594501	rs16833239	rs11889341
	1	G	C	C	46.4	50.0	0.222
	2	G	C	T	40.3	32.2	3.5×10^−3	1.43	1.12–1.81
	3	A	T	C	11.9	15.9	0.045
B		rs7574865	rs8179673	rs10181656
	4	G	A	C	53.9	65.4	5.0×10^−5	0.62	0.49–0.78
	5	T	G	G	43.3	33.6	6.0×10^−4	1.51	1.19–1.91
	6	G	A	G	2.1	0.0	3.0×10^−4

STAT4: signal transducer activator transcription 4; PBC: primary biliary cirrhosis; SNP: single nucleotide polymorphism; OR: odds ratio; CI: confidence interval; 𝑛^∗: values for 𝑛^∗ indicate two times the number of individuals since each person carries two haplotypes.