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Disease Markers
Volume 2014, Article ID 736536, 7 pages
http://dx.doi.org/10.1155/2014/736536
Clinical Study

A Comparison of KL-6 and Clara Cell Protein as Markers for Predicting Bronchopulmonary Dysplasia in Preterm Infants

1Department of Central Laboratory, Hangzhou First People’s Hospital, No. 261 Huansha Road, Hangzhou, Zhejiang 310002, China
2Department of Pediatrics, Hangzhou First People’s Hospital, No. 261 Huansha Road, Hangzhou, Zhejiang 310002, China
3Division of Neonatology, Department of Pediatrics, Hangzhou First People’s Hospital, No. 261 Huansha Road, Hangzhou, Zhejiang 310002, China

Received 20 March 2014; Revised 16 July 2014; Accepted 15 August 2014; Published 27 August 2014

Academic Editor: Ralf Lichtinghagen

Copyright © 2014 Keyi Wang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Objectives. To evaluate the predictive characteristics of KL-6 and CC16 for bronchopulmonary dysplasia (BPD) in preterm infants, either independently or in combination. Study Design. This prospective cohort study was performed from 2011 to 2013 with preterm neonates of gestational age ≤32 weeks and birth weight ≤1500 g. Serum KL-6 and CC16 levels were determined 7 and 14 days after birth. Results. Seventy-three preterm infants were studied. BPD was identified in 24 of these infants. After adjusting for potential confounders, serum KL-6 concentrations were found to be elevated in BPD infants at both time points relative to non-BPD infants, while serum CC16 concentrations were lower at 14 days. At both 7 d and 14 d of life the predictive power of KL-6 levels exceeded that of CC16 (area under receiver operating characteristic curve: at 7 d, 0.91 cf. 0.73, ; at 14 d, 0.95 cf. 0.85, ). The combination of these markers enhanced the sensitivity further. Conclusions. Serum KL-6 levels higher than 79.26 ng/mL at 14 days postpartum in preterm infants predict the occurrence of BPD. CC16 was less predictive than KL-6 at this time point, but KL-6 and CC16 together enhanced the prediction.