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Disease Markers
Volume 2014 (2014), Article ID 829706, 8 pages
http://dx.doi.org/10.1155/2014/829706
Research Article

Elevated Plasma Stromal-Cell-Derived Factor-1 Protein Levels Correlate with Severity in Patients with Community-Acquired Pneumonia

1Department of Internal Medicine, Zuoying Branch of Kaohsiung Armed Forces General Hospital, Kaohsiung 813, Taiwan
2Department of Emergency Medicine, Chung Shan Medical University Hospital, Taichung 402, Taiwan
3Institute of Medicine, Chung Shan Medical University, No. 110, Section 1, Chien-Kuo N. Road, Taichung 402, Taiwan
4Cancer Research Center, Changhua Christian Hospital, Changhua 500, Taiwan
5Department of Beauty Science, National Taichung University of Science and Technology, Taichung 403, Taiwan
6School of Medicine, Chung Shan Medical University, Taichung 402, Taiwan
7Department of Medical Research, Chung Shan Medical University Hospital, Taichung 402, Taiwan
8Department of Emergency Medicine, School of Medicine, Chung Shan Medical University, Taichung 402, Taiwan

Received 28 April 2014; Revised 2 September 2014; Accepted 18 September 2014; Published 13 October 2014

Academic Editor: Carlo Chiarla

Copyright © 2014 Ping-Kun Tsai et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. The aim of this study was to investigate differential changes in plasma levels of stromal-cell-derived factor-1 (SDF-1) before and after antibiotic treatment in patients with community-acquired pneumonia (CAP) and observe the association between the severity of CAP and the plasma SDF-1 level. Methods. We gathered blood specimens from 61 adult CAP patients before and after antibiotic treatment and from 60 healthy controls to measure the plasma concentrations of SDF-1 by using an enzyme-linked immunosorbent assay. Results. The plasma SDF-1 concentration was elevated significantly in patients with CAP before receiving treatment compared with the controls and decreased significantly after the patients received treatment. Leukocyte (WBC) and neutrophil counts and C-reactive protein (CRP) levels decreased significantly after antibiotic treatment. Moreover, differences in the plasma concentration of SDF-1 were significantly correlated with PSI, CURB-65, and APACHE II scores (, , and ; , , and ; and , , and , resp.). Conclusions. An elevated plasma SDF-1 concentration can be used as a biological marker for the early diagnosis of CAP and for the early detection of its severity.