Two Polymorphisms in the Fractalkine Receptor CX3CR1 Gene Influence the Development of Atherosclerosis: A Meta-Analysis

Table 3

The independent effect of each genotype/haplotype on susceptibility to atherosclerosis.

Genotype	Cases ()	Controls ()	Baseline risk	OR	95% CI		(%)
VVTT	1923	2601		1
VVTM	49	3	VVTT	11.95	5.00–28.58	<0.001	0	0.44
VITT	516	700	VVTT	1.11	0.96–1.27	0.16	31.4	0.13
VITM	605	1211	VVTT	0.64	0.50–0.82	<0.001	69.2	<0.1
IITT	64	76	VVTT	1.20	0.83–1.74	0.33	0	0.46
IITM	100	182	VVTT	0.69	0.52–0.90	<0.01	41.7	<0.1
IIMM	87	151	VVTT	0.76	0.57–1.02	0.06	0	0.79
VV	4813	3556		1
VI	2598	2016	VV	0.84	0.72–0.98	0.02	65.9	<0.1
VI (CAD)	1843	1227	VV (CAD)	0.72	0.59–0.90	<0.01	68.1	<0.1
II	541	463	VV	0.81	0.62–1.05	0.12	61.6	<0.1
TT	5786	4293		1
TM	1743	1456	TT	0.81	0.66–0.99	0.04	76.2	<0.1
TM (CAD)	1193	871	TT (CAD)	0.67	0.52–0.87	<0.01	72.2	<0.1
MM	203	156	TT	0.96	0.77–1.19	0.72	31.9	0.08
MM (ICVD)	47	16	TT (ICVD)	2.88	1.64–5.04	<0.001	0	0.92
VT	5377	6975		1
VM	77	5	VT	11.47	5.34–24.64	<0.001	43.0	0.12
IT	814	1007	VT	1.09	0.97–1.21	0.14	0	0.55
IM	892	1665	VT	0.63	0.50–0.81	<0.001	82.2	<0.1

, value for Cochran’s statistic.