The Clinicopathological Significance of miR-133a in Colorectal Cancer
Table 1
Association of clinicopathological factors in colorectal cancer patients and expression of mir-133a in tumor tissue. A higher ΔΔ value indicates lower expression; positive values represent downregulation.
Variables
Patients,
MiR-133a expression
value†
( = 125)a
Mean ΔΔ value ± SD
Age
0.938
≤65
36
4.440 ± 0.4927
>65
89
4.488 ± 0.3301
Gender
0.977
Male
73
4.517 ± 0.3569
Female
51
4.501 ± 0.4332
Dukes
0.0481*
A, B
42
5.139 ± 0.5392
C, D
36
3.716 ± 0.4348
Tumor size
0.2643
<5 cm
68
4.739 ± 0.3548
≥5 cm
55
4.124 ± 0.4228
Histological type
0.3664
Well, moderate
78
4.681 ± 0.3499
Poor, mucinous
5
3.395 ± 1.172
Depth of invasion
0.2158
T1, T2
16
5.400 ± 0.7513
T3, T4
100
4.352 ± 0.3146
TNM stage
0.0031*
I, II
60
5.316 ± 0.3887
III, IV
62
3.667 ± 0.3835
Location
0.9658
Colon
90
4.527 ± 0.3259
Rectum
32
4.554 ± 0.5298
Lymph node metastasis
0.0595
Absent
68
4.926 ± 0.3629
Present
55
3.893 ± 0.4034
Distant metastasis
0.0020*
Absent
95
4.983 ± 0.3188
Present
28
2.932 ± 0.5104
The total number of cases may be less than 125 as some information was unavailable. † values are based on Student’s -test. SD: standard deviation; .
