Table of Contents Author Guidelines Submit a Manuscript
Disease Markers
Volume 2014, Article ID 931083, 10 pages
http://dx.doi.org/10.1155/2014/931083
Review Article

Systemic Oxidative Stress Biomarkers in Chronic Periodontitis: A Meta-Analysis

1Department of Stomatology, Beijing ChaoYang Hospital Affiliated to Capital Medical University, Beijing 100020, China
2Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction, Capital Medical University School of Stomatology, Beijing 100050, China
3Department of Epidemiology, Indiana University Richard M. Fairbanks School of Public Health, Indianapolis, IN 46202, USA
4Institute of Vascular Medicine, Peking University Third Hospital, Beijing 100191, China
5Laboratory of Gene Therapy and Tooth Regeneration, Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction, Capital Medical University School of Stomatology, Beijing 100050, China

Received 2 August 2014; Revised 10 October 2014; Accepted 13 October 2014; Published 16 November 2014

Academic Editor: Seul-Ki Jeong

Copyright © 2014 Zhiqiang Liu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Oxidative stress biomarkers have been observed in peripheral blood of chronic periodontitis patients; however, their associations with periodontitis were not consistent. This meta-analysis was performed to clarify the associations between chronic periodontitis and oxidative biomarkers in systemic circulation. Electronic searches of PubMed and Embase databases were performed until October 2014 and articles were selected to meet inclusion criteria. Data of oxidative biomarkers levels in peripheral blood of periodontitis patients and periodontal healthy controls were extracted to calculate standardized mean differences (SMDs) and 95% confidence intervals (CIs) by using random-effects model. Of 31 eligible articles, 16 articles with available data were included in meta-analysis. Our results showed that periodontitis patients had significantly lower levels of total antioxidant capacity (SMD = −2.02; 95% CI: −3.08, −0.96; ) and higher levels of malondialdehyde (SMD = 0.99; 95% CI: 0.12, 1.86; ) and nitric oxide (SMD = 4.98; 95% CI: 2.33, 7.63; ) than periodontal healthy control. Superoxide dismutase levels between two groups were not significantly different (SMD = −1.72; 95% CI: −3.50, 0.07; ). In conclusion, our meta-analysis showed that chronic periodontitis is significantly associated with circulating levels of three oxidative stress biomarkers, indicating a role of chronic periodontitis in systemic diseases.