Research Article
Prognostic Value of Rab27B Nuclear Expression in Gastrointestinal Stromal Tumors
Table 1
Association of Rab27B expression with clinical parameters of GIST.
| Groups | Number | Rab27B | Low or no expression (%) | High expression (%) | Pearson | value |
| Total | 162 | 74 (45.68) | 88 (54.32) | | | Gender | | | | 0.012 | 0.913 | Male | 73 | 33 (45.21) | 40 (54.79) | | | Female | 89 | 41 (46.07) | 48 (53.93) | | | Age | | | | 0.054 | 0.816 | ≤60 years | 98 | 44 (44.90) | 54 (55.10) | | | >60 years | 62 | 29 (46.77) | 33 (53.23) | | | Unknown | 2 | 1 | 1 | | | Tumor size | | | | 10.228 | 0.006* | <5 cm | 40 | 21 (52.50 | 19 (47.50) | | | 5–10 cm | 78 | 41 (52.56) | 37 (47.44) | | | ≥10 cm | 36 | 8 (22.22) | 28 (77.78) | | | Unknown | 8 | 4 | 4 | | | Mitotic index (per 50 HPFs) | | | | 8.639 | 0.013* | 0–5 | 67 | 38 (56.72) | 29 (43.28) | | | 6–10 | 54 | 24 (44.44) | 30 (55.56) | | | >10 | 26 | 6 (23.08) | 20 (76.92) | | | Unknown | 15 | 6 | 9 | | | Gross classification | | | | 0.184 | 0.668 | Single nodule | 11 | 4 (36.36) | 7 (63.64) | | | Multiple nodules | 18 | 8 (44.44) | 10 (55.56) | | | Unknown | 133 | 62 | 71 | | | Tumor location | | | | 0.571 | 0.752 | Stomach | 81 | 37 (45.68) | 44 (54.32) | | | Intestine | 56 | 24 (42.86) | 32 (57.14) | | | Others | 23 | 12 (52.17) | 11 (47.83) | | | Unknown | 2 | 1 | 1 | | | AFIP Miettinen risk classification | | | | 9.182 | 0.002* | Very low-low risk | 34 | 20 (58.82) | 14 (41.18) | | | Moderate-high risk | 41 | 10 (24.39) | 31 (75.61) | | | Unknown | 87 | 44 | 43 | | | Grade | | | | 9.703 | 0.021* | 1 | 48 | 30 (62.50) | 18 (37.50) | | | 2 | 60 | 27 (45.00) | 33 (55.00) | | | 3 | 28 | 8 (28.57) | 20 (71.43) | | | 4 | 10 | 3 (30.00) | 7 (70.00) | | | Unknown | 16 | 6 | 10 | | |
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; HPFs: high-power fields.
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