Adiponectin as a Biomarker of Osteoporosis in Postmenopausal Women: Controversies

Table 1

Concentrations of adiponectin and bone mineral density in men and women.

Characteristics of the respondents			Mean ± SD or median (range)						Author
			Age; (years)	BMI; (kg/m^2)	Fat-free mass (kg)	Spine BMD; (g/cm^2)	Total BMD; (g/cm^2)	Adiponectin; (μg/mL)
Male	Hemodialysis patients	𝑛=114	61.0±11.1	22.0±3.1	21.5±7.1 (%)	1.019±0.168	—	17.7 (3.1–71.5)	Okuno et al. (2012) [52]
	nondiabetic	𝑛=1164	48.6±14.0	27.1±3.9	—	1.18±1.94	1.21±0.10	8.0±4.1	Zillikens et al. (2010) [53]
Female	Total; (pre- and postmenopausal)	𝑛=1467 adult	47.7±14.2	26.4±4.7	—	1.12±0.16	1.10±0.95	12.3±5.8	Zillikens et al. (2010) [53]
		𝑛=153 adult	57.8±13.7	27.6±2.4	43.3±4.0	1.18±0.21	1.18±0.12	12.2±6.3	J. Jürimäe and T. Jürimäe (2007) [51]
		𝑛=1735 adult	50.0±13.0	25.5±4.7	23.06±8.5	1.00±0.1	—	8.3 (3.9)	Richards et al. (2007) [54]
	Premenopausal	𝑛=98 adult	45.2±4.3	29.9±6.2	45.0±4.6	1.24±0.17	1.23±0.12	12.0±4.7	J. Jürimäe and T. Jürimäe (2007) [51]
		middle-age 𝑛=42	40.8±5.7	25.9±2.8	45.0±4.8	1.35±0.18	1.26±0.11	8.4±3.2	J. Jürimäe and T. Jürimäe (2007) [51]
		𝑛=25 adult	47.80±3.14	30.01±5.22	42.90±4.92	1.23±0.16	—	7.9±5.81	Kontogianni et al. (2004) [55]
		𝑛=105 adolescents	15.4±1.9	23.1±4.0	24.7±9.3	0.940±0.104	—	30.79±14.48	Huang et al. (2004) [56]
	Postmenopausal non-diabetic; (with hip fracture) 𝑛=105	nonosteoporosis	58.4±8.2	31.2±5.9	—	0.93±0.11	—	6.33±0.51	Özkurt (2009) [26]
		osteoporosis	68.4±8.0	25.5±9.9	—	0.77±0.2	—	6.99±0.5
		Total	63.4±8.1	28.5±7.9	—		—	6.66±0.45
	Postmenopausal	𝑛=84	52.5	29.4	—	0.889	—	13.25	Ağbaht et al. (2009) [12]
		middle-age 𝑛=49	56.7±3.6	28.3±2.6	42.5±3.8	1.15±0.16^∗	1.17±0.09	12.0±5.1	J. Jürimäe and T. Jürimäe (2007) [51]
		older 𝑛=62	72.2±4.5	28.5±2.0	42.6±3.0	1.05±0.17	1.12±0.12	15.3±7.3
		𝑛=55	54.47±5.36	28.89±4.19	40.36±4.56	1.13±0.18	—	11.94±7.00	Kontogianni et al. (2004) [55]
Male & Female; (nondiabetic)	Nonosteoporotic	𝑛=120	39.7±10.4	28.8±4.4	—	−0.63±0.43	—	8.03±4.2	Mohiti-Ardekani et al. (2013) [57]
	Osteoporotic	𝑛=81	54.4±15.5	28.2±4.6	—	−3.25±1.1	—	10.7±4.5