Table of Contents Author Guidelines Submit a Manuscript
Disease Markers
Volume 2015, Article ID 127083, 8 pages
http://dx.doi.org/10.1155/2015/127083
Research Article

Is It Possible to Differentiate Chronic Kidney Disease and Preeclampsia by means of New and Old Biomarkers? A Prospective Study

1Department of Surgical Sciences, O.I.R.M-Sant’Anna Hospital, University of Turin, Via Ventimiglia 3, 10126 Turin, Italy
2SS Nephrology, Department of Clinical and Biological Sciences, San Luigi Gonzaga Hospital, University of Turin, 10043 Orbassano, Italy
3Chemical-Clinical and Microbiological Analysis Laboratory, Giovanni Bosco Hospital, 10154 Turin, Italy
4Service of Biostatistics, Department of Hematology, Niguarda Ca’ Granda Hospital, 20162 Milan, Italy

Received 24 June 2015; Accepted 9 September 2015

Academic Editor: Gad Rennert

Copyright © 2015 Alessandro Rolfo et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. S. Lisonkova and K. S. Joseph, “Incidence of preeclampsia: risk factors and outcomes associated with early-versus late-onset disease,” American Journal of Obstetrics & Gynecology, vol. 209, no. 6, pp. 544.e1–544.e12, 2013. View at Publisher · View at Google Scholar · View at Scopus
  2. N. Arulkumaran and L. Lightstone, “Severe pre-eclampsia and hypertensive crises,” Best Practice and Research: Clinical Obstetrics and Gynaecology, vol. 27, no. 6, pp. 877–884, 2013. View at Publisher · View at Google Scholar · View at Scopus
  3. E. Ciantar and J. J. Walker, “Pre-eclampsia, severe pre-eclampsia and hemolysis, elevated liver enzymes and low platelets syndrome: what is new?” Women's Health, vol. 7, no. 5, pp. 555–569, 2011. View at Publisher · View at Google Scholar · View at Scopus
  4. Z. Al-Safi, A. N. Imudia, L. C. Filetti, D. T. Hobson, R. O. Bahado-Singh, and A. O. Awonuga, “Delayed postpartum preeclampsia and eclampsia: demographics, clinical course, and complications,” Obstetrics & Gynecology, vol. 118, no. 5, pp. 1102–1107, 2011. View at Publisher · View at Google Scholar · View at Scopus
  5. 2015, http://www.kidney.org/.
  6. D. Williams and J. Davison, “Chronic kidney disease in pregnancy,” British Medical Journal, vol. 336, no. 7637, pp. 211–215, 2008. View at Publisher · View at Google Scholar · View at Scopus
  7. D. Berks, E. A. P. Steegers, M. Molas, and W. Visser, “Resolution of hypertension and proteinuria after preeclampsia,” Obstetrics and Gynecology, vol. 114, no. 6, pp. 1307–1314, 2009. View at Publisher · View at Google Scholar · View at Scopus
  8. K. Duckitt and D. Harrington, “Risk factors for pre-eclampsia at antenatal booking: systematic review of controlled studies,” British Medical Journal, vol. 330, no. 7491, pp. 565–567, 2005. View at Publisher · View at Google Scholar · View at Scopus
  9. Publications Committee, Society for Maternal-Fetal Medicine, and B. M. Sibai, “Evaluation and management of severe preeclampsia before 34 weeks' gestation,” American Journal of Obstetrics and Gynecology, vol. 205, no. 3, pp. 191–198, 2011. View at Publisher · View at Google Scholar
  10. Y. Mikami, K. Takagi, Y. Itaya et al., “Post-partum recovery course in patients with gestational hypertension and pre-eclampsia,” Journal of Obstetrics and Gynaecology Research, vol. 40, no. 4, pp. 919–925, 2014. View at Publisher · View at Google Scholar · View at Scopus
  11. http://www.acog.org/Resources_And_Publications/Task_Force_and_Work_Group_Reports/Hypertension_in_Pregnancy.
  12. B. Jim and S. Hou, “Pregnancy and kidney disease—the miracle continues against all odds,” Advances in Chronic Kidney Disease, vol. 20, no. 3, pp. 206–208, 2013. View at Publisher · View at Google Scholar · View at Scopus
  13. V. D. Garovic, S. J. Wagner, S. T. Turner et al., “Urinary podocyte excretion as a marker for preeclampsia,” American Journal of Obstetrics & Gynecology, vol. 196, no. 4, pp. 320.e1–320.e7, 2007. View at Publisher · View at Google Scholar · View at Scopus
  14. W. M. White, A. T. Garrett, I. M. Craici et al., “Persistent urinary podocyte loss following preeclampsia may reflect subclinical renal injury,” PLoS ONE, vol. 9, no. 3, Article ID e92693, 2014. View at Publisher · View at Google Scholar · View at Scopus
  15. T. C. Allbutt, “Albuminuria in pregnancy,” The Lancet, vol. 149, no. 3835, pp. 579–582, 1897. View at Publisher · View at Google Scholar · View at Scopus
  16. G. B. Piccoli, P. Gaglioti, R. Attini et al., “Pre-eclampsia or chronic kidney disease? the flow hypothesis,” Nephrology Dialysis Transplantation, vol. 28, no. 5, pp. 1199–1206, 2013. View at Publisher · View at Google Scholar · View at Scopus
  17. A. Rolfo, R. Attini, A. M. Nuzzo et al., “Chronic kidney disease may be differentially diagnosed from preeclampsia by serum biomarkers,” Kidney International, vol. 83, no. 1, pp. 177–181, 2013. View at Publisher · View at Google Scholar · View at Scopus
  18. M. Parra, R. Rodrigo, P. Barja et al., “Screening test for preeclampsia through assessment of uteroplacental blood flow and biochemical markers of oxidative stress and endothelial dysfunction,” American Journal of Obstetrics & Gynecology, vol. 193, no. 4, pp. 1486–1491, 2005. View at Publisher · View at Google Scholar · View at Scopus
  19. A. T. Papageorghiou and N. Roberts, “Uterine artery Doppler screening for adverse pregnancy outcome,” Current Opinion in Obstetrics and Gynecology, vol. 17, no. 6, pp. 584–590, 2005. View at Publisher · View at Google Scholar · View at Scopus
  20. R. Gaillard, L. R. Arends, E. A. P. Steegers, A. Hofman, and V. W. V. Jaddoe, “Second- and third-trimester placental hemodynamics and the risks of pregnancy complications,” American Journal of Epidemiology, vol. 177, no. 8, pp. 743–754, 2013. View at Publisher · View at Google Scholar · View at Scopus
  21. S. Rana, C. E. Powe, S. Salahuddin et al., “Angiogenic factors and the risk of adverse outcomes in women with suspected preeclampsia,” Circulation, vol. 125, no. 7, pp. 911–919, 2012. View at Publisher · View at Google Scholar · View at Scopus
  22. T. A. M. Simas, S. L. Crawford, M. J. Solitro, S. C. Frost, B. A. Meyer, and S. E. Maynard, “Angiogenic factors for the prediction of preeclampsia in high-risk women,” American Journal of Obstetrics & Gynecology, vol. 197, no. 3, pp. 244.e1–244.e8, 2007. View at Publisher · View at Google Scholar · View at Scopus
  23. K. E. Duhig, L. C. Chappell, and A. H. Shennan, “How placental growth factor detection might improve diagnosis and management of pre-eclampsia,” Expert Review of Molecular Diagnostics, vol. 14, no. 4, pp. 403–406, 2014. View at Publisher · View at Google Scholar · View at Scopus
  24. S. Verlohren, I. Herraiz, O. Lapaire et al., “The sFlt-1/PlGF ratio in different types of hypertensive pregnancy disorders and its prognostic potential in preeclamptic patients,” American Journal of Obstetrics & Gynecology, vol. 206, no. 1, pp. 58.e1–58.e8, 2012. View at Publisher · View at Google Scholar · View at Scopus
  25. C. E. Kleinrouweler, M. M. J. Wiegerinck, C. Ris-Stalpers et al., “Accuracy of circulating placental growth factor, vascular endothelial growth factor, soluble fms-like tyrosine kinase 1 and soluble endoglin in the prediction of pre-eclampsia: a systematic review and meta-analysis,” BJOG, vol. 119, no. 7, pp. 778–787, 2012. View at Publisher · View at Google Scholar · View at Scopus
  26. R. W. Powers, A. Jeyabalan, R. G. Clifton et al., “Soluble fms-like tyrosine kinase 1 (sFlt1), endoglin and placental growth factor (PlGF) in preeclampsia among high risk pregnancies,” PLoS ONE, vol. 5, no. 10, Article ID e13263, 2010. View at Publisher · View at Google Scholar · View at Scopus
  27. T. D. Metz, A. A. Allshouse, A. G. Euser, and K. D. Heyborne, “Preeclampsia in high risk women is characterized by risk group-specific abnormalities in serum biomarkers,” American Journal of Obstetrics & Gynecology, vol. 211, no. 5, pp. 512.e1–512.e6, 2014. View at Publisher · View at Google Scholar · View at Scopus
  28. P. I. Gómez-Arriaga, I. Herraiz, E. A. López-Jiménez, E. Gómez-Montes, B. Denk, and A. Galindo, “Uterine artery Doppler and sFlt-1/PlGF ratio: usefulness in diagnosis of pre-eclampsia,” Ultrasound in Obstetrics & Gynecology, vol. 41, no. 5, pp. 530–537, 2013. View at Publisher · View at Google Scholar
  29. J.-C. Forest, S. Thériault, J. Massé, E. Bujold, and Y. Giguère, “Soluble Fms-like tyrosine kinase-1 to placental growth factor ratio in mid-pregnancy as a predictor of preterm preeclampsia in asymptomatic pregnant women,” Clinical Chemistry and Laboratory Medicine, vol. 52, no. 8, pp. 1169–1178, 2014. View at Publisher · View at Google Scholar · View at Scopus
  30. G. B. Piccoli, F. Fassio, R. Attini et al., “Pregnancy in CKD: whom should we follow and why?” Nephrology Dialysis Transplantation, vol. 27, supplement 3, pp. iii111–iii118, 2012. View at Publisher · View at Google Scholar · View at Scopus
  31. G. B. Piccoli, R. Attini, E. Vasario et al., “Pregnancy and chronic kidney disease: a challenge in all CKD stages,” Clinical Journal of the American Society of Nephrology, vol. 5, no. 5, pp. 844–855, 2010. View at Publisher · View at Google Scholar · View at Scopus
  32. S. Verlohren, A. Galindo, D. Schlembach et al., “An automated method for the determination of the sFlt-1/PIGF ratio in the assessment of preeclampsia,” American Journal of Obstetrics & Gynecology, vol. 202, no. 2, pp. 161.e1–161.e11, 2010. View at Publisher · View at Google Scholar · View at Scopus
  33. M. A. G. Coleman, L. M. E. McCowan, and R. A. North, “Mid-trimester uterine artery Doppler screening as a predictor of adverse pregnancy outcome in high-risk women,” Ultrasound in Obstetrics and Gynecology, vol. 15, no. 1, pp. 7–12, 2000. View at Publisher · View at Google Scholar · View at Scopus
  34. C. Guiot, P. Gaglioti, M. Oberto, E. Piccoli, R. Rosato, and T. Todros, “Is three-dimensional power Doppler ultrasound useful in the assessment of placental perfusion in normal and growth-restricted pregnancies?” Ultrasound in Obstetrics and Gynecology, vol. 31, no. 2, pp. 171–176, 2008. View at Publisher · View at Google Scholar · View at Scopus
  35. June 2014, http://www.inescharts.com/.
  36. S. E. Maynard, S. L. Crawford, S. Bathgate et al., “Gestational angiogenic biomarker patterns in high risk preeclampsia groups,” American Journal of Obstetrics and Gynecology, vol. 209, no. 1, pp. 53.e1–53.e9, 2013. View at Publisher · View at Google Scholar · View at Scopus
  37. C. M. Koopmans, D. Bijlenga, H. Groen et al., “Induction of labour versus expectant monitoring for gestational hypertension or mild pre-eclampsia after 36 weeks' gestation (HYPITAT): a multicentre, open-label randomised controlled trial,” The Lancet, vol. 374, no. 9694, pp. 979–988, 2009. View at Publisher · View at Google Scholar · View at Scopus
  38. 2015, http://www.snlg-iss.it/cms/files/LG_Gravidanza.pdf.
  39. 2015, http://www.nice.org.uk/guidance/cg62/resources/guidance-antenatal-care-pdf.