Matrix Metalloproteinase-9/Neutrophil Gelatinase-Associated Lipocalin Complex Activity in Human Glioma Samples Predicts Tumor Presence and Clinical Prognosis

Table 2

Comparison of MMP-9/NGAL activity in serial samples of glioma to clinicopathological characteristics.

Characteristics	MMP-9/NGAL activity
	TT		Preop-1d urine		Postop-1d urine		Post-1w urine
Tumor grade
Low-grade	5.0	0.027	4.0	0.031	58.5	>0.05	1.0	>0.05
High-grade	20.5		9.5		121.0		7.0
Astrocytic tumors
Low-grade	6.5	0.018	3.0	0.025	50.0	>0.05	1.0	0.029
High-grade	21.0		9.0		133.0		7.0
Tumor size (cm^3)
≤100	11.0	0.030	4.0	0.030	49.0	>0.05	4.0	>0.05
>100	30.5		16.0		71.0		10.5

MMP-9/NGAL activity: the median of relative densitometric units detected by gelatin zymography; Tumor size (cm³): 28 cases high-grade gliomas were measured; ≤100: 13 cases; >100: 15 cases (TT: tumor tissue; Preop-1d, Postop-1d, and Postop-1w urine: fresh urine samples were collected in the morning one day prior to surgery, the day after surgery, and one week after surgery).