Research Article
Effect of Extended-Release Niacin/Laropiprant Combination on Plasma Adiponectin and Insulin Resistance in Chinese Patients with Dyslipidaemia
Table 1
Changes in anthropometric and biochemical parameters during the study.
| | Baseline | After treatment | % changes | |
| Body weight (kg) | 73.1 ± 15.5 | 72.5 ± 15.2 | −0.7 ± 2.0 | <0.001 | Body fat (%) | 31.2 ± 7.2 | 29.8 ± 7.4 | −4.7 ± 8.4 | <0.001 | Fat mass (kg) | 22.8 ± 7.5 | 21.6 ± 7.5 | −5.4 ± 8.7 | <0.001 | Lean body mass (kg) | 50.2 ± 11.4 | 50.8 ± 11.4 | 1.5 ± 4.3 | 0.02 | BMI (kg/m2) | 27.5 ± 4.4 | 27.3 ± 4.3 | −0.7 ± 2.3 | <0.001 | Waist circumference (cm) | 92.4 ± 11.1 | 92.3 ± 11.7 | −0.2 ± 3.9 | 0.633 | Total cholesterol (mmol/L) | 5.39 ± 1.00 | 4.56 ± 0.96 | −14.5 ± 14.8 | <0.001 | HDL-C (mmol/L) | 1.19 ± 0.27 | 1.45 ± 0.38 | 23.3 ± 22.7 | <0.001 | Triglycerides (mmol/L) | 2.29 ± 1.25 | 1.44 ± 0.84 | −31.8 ± 29.2 | <0.001 | LDL-C (mmol/L) | 3.19 ± 0.92 | 2.46 ± 0.83 | −19.8 ± 26.2 | <0.001 | Non-HDL (mmol/L) | 4.20 ± 0.95 | 3.12 ± 0.93 | −24.7 ± 18.8 | <0.001 | Free fatty acids (μEq/L) | 481.8 ± 204.3 | 745.3 ± 351.5 | 74.5 ± 105.3 | <0.001 | Fasting glucose (mmol/L) | 5.62 ± 1.12 | 6.15 ± 1.47 | 9.4 ± 13.1 | <0.001 | HbA1C (%) | 6.33 ± 0.72 | 6.63 ± 0.87 | 4.8 ± 7.4 | <0.001 | Fasting insulin, mU/L | 11.95 ± 8.54 | 17.34 ± 10.44 | 70.2 ± 91.0 | <0.001 | HOMA-IR | 3.03 ± 2.31 | 4.78 ± 3.07 | 87.8 ± 103.9 | <0.001 | Adiponectin, µg/mL | 10.32 ± 6.60 | 28.11 ± 22.4 | 169.3 ± 111.6 | <0.001 |
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BMI: body mass index; HbA1C: glycated haemoglobin; HDL-C: high-density lipoprotein cholesterol; HOMA-IR: Homeostasis Model of Assessment-Insulin Resistance; LDL-C: low-density lipoprotein cholesterol.
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