Helicobacter pylori Antibody Titer and Gastric Cancer Screening

Figure 1

Time course of changes in the H. pylori antibody titer in H. pylori-infected subjects without significant progression of mucosal atrophy (Grade B in the ABC method). The antibody titer does not show significant change in most Group B cases. An increase in the H. pylori antibody titer is observed in a subset of these patients with progressive mucosal inflammation; such cases have an increased risk for diffuse-type cancer. Thus, subjects with a high-positive antibody titer should be considered at high risk for future development of diffuse-type gastric cancer.