Role of MALAT1 as a Prognostic Factor for Survival in Various Cancers: A Systematic Review of the Literature with Meta-Analysis

Table 1

Characteristics of the studies included in the meta-analysis.

First author	Year	Country	Cancer type	Stage	Sample size ()	Method	Cut-off	Follow-up (months)	Outcome	Survival analysis
Pang [15]	2015	China	Pancreatic cancer	I–IV	126	RT-qPCR	Median value of 6.23	5–60	OS	Univariate and multivariate
Zhang [10]	2014	China	Renal cell carcinoma (clear cell)	I–IV	106	RT-qPCR	Mean value of 3.85	NA	OS	Univariate and multivariate
Liu [29]	2014	China	Pancreatic duct adenocarcinoma	I–IV	45	RT-qPCR	Mean value (NA)	24–36	DSS	Univariate and multivariate
Zheng [11]	2014	China	Colorectal cancer	II-III	146	RT-qPCR	6.15 (MALAT1/GAPDH ratio)	11–72.8	DFS, OS	Univariate and multivariate
Schmidt [7]	2011	Germany	Non-small-cell lung cancer (squamous cell)	I–III	102	ISH	A large gene copy cluster in 50% of cells	NA	OS	Univariate and multivariate
Okugawa [12]	2014	Japan	Gastric cancer	I–IV	150	RT-qPCR	Threshold of 0.985	1–78	OS	Univariate and multivariate
Shen [8]	2014	China	Non-small-cell lung cancer	NA	79	RT-qPCR	Mean value (NA)	NA	DFS	Univariate
Lai [9]	2012	China	Hepatocellular carcinoma	NA	60	RT-qPCR	NA	18.6 (median)	DFS	Univariate and multivariate
Ma [18]	2015	China	Glioma	I–IV	118	RT-qPCR	Median value of 5.18	5 years	OS	Univariate and multivariate

RT-qPCR: real-time quantitative PCR; ISH: in situ hybridization; OS: overall survival; DFS: disease-free survival; DSS: disease-specific survival; NA: not available.