Role of MALAT1 as a Prognostic Factor for Survival in Various Cancers: A Systematic Review of the Literature with Meta-Analysis

Table 3

The main results of the pooled analyses.

Survival	Variables	Number of studies	Number of patients	HR	95% CI	value	Heterogeneity (, %)
OS	All	7	793	2.02	1.62–2.52	<0.001	0
	Tumor type
	Digestive system	4	467	1.86	1.37–2.53	<0.001	14.2
	Nondigestive system	3	326	2.21	1.61–3.02	<0.001	0
	Histology type
	Adenocarcinoma	5	573	2.03	1.53–2.68	<0.001	24.2
	Squamous carcinoma	1	102	1.78	1.08–2.92
	Others	1	118	2.29	1.37–3.81
	Ethnicity
	Asian	6	691	2.08	1.63–2.66	<0.001	8.1
	Caucasian	1	102	1.78	1.08–2.92
	Method
	RT-qPCR	6	691	2.08	1.63–2.66	<0.001	8.1
	ISH	1	102	1.78	1.08–2.92
DFS	All	3	285	2.78	1.87–4.15	<0.001	0

RT-qPCR: real-time quantitative PCR; ISH: in situ hybridization; OS: overall survival; DFS: disease-free survival.