Research Article
Association of High Expression of Groβ with Clinical and Pathological Characteristics of Unfavorable Prognosis in Gastrointestinal Stromal Tumors
Table 3
Univariate and multivariable analysis of prognostic factors in GIST for 5-year and 10-year survival.
| Variable | Years | Univariate analysis | Multivariate analysis | HR | value | 95% CI | HR | value | 95% CI |
| Cytoplasmic expression of GROβ | | | | | | | | High versus low | 10 | 2.521 | 0.009* | 1.263–5.033 | 2.479 | 0.023* | 1.135–5.418 | 5 | 2.290 | 0.033* | 1.071–4.895 | 1.927 | 0.133 | 0.819–4.537 | Nuclear expression of GROβ | | | | | | | | High versus low | 10 | 3.280 | 0.001* | 1.611–6.677 | 2.082 | 0.071 | 0.939–4.619 | 5 | 3.637 | 0.002* | 1.631–8.110 | 2.039 | 0.111 | 0.849–4.898 | Age (years) | | | | | | | | 60 versus >60 | 10 | 1.215 | 0.583 | 0.606–2.435 | | | | 5 | 1.080 | 0.841 | 0.507–2.300 | | | | Tumor size (cm) | | | | | | | | | 10 | 2.265 | 0.002* | 1.360–3.772 | 3.182 | 0.076 | 0.884–11.448 | 5 | 1.992 | 0.015* | 1.145–3.466 | 3.559 | 0.098 | 0.792-15.982 | Mitotic index (per 50 HPFs) | | | | | | | | 0–5 versus >6 | 10 | 3.038 | 0.001* | 1.869–4.937 | 2.695 | 0.095 | 0.842–8.632 | 5 | 3.737 | 0.001* | 2.117–6.598 | 6.086 | 0.026* | 1.240–29.869 | Growth pattern | | | | | | | | Single versus multiple | 10 | 1.381 | 0.475 | 0.569–3.349 | | | | 5 | 1.472 | 0.435 | 0.557–3.888 | | | | Tumor location | | | | | | | | Stomach versus intestine versus others | 10 | 1.357 | 0.218 | 0.835–2.203 | | | | 5 | 1.320 | 0.306 | 0.776–2.245 | | | | AFIP-Miettinen risk classification | | | | | | | | Very low-low risk versus moderate-high risk | 10 | 2.374 | 0.001* | 1.617–3.484 | 3.011 | 0.120 | 0.751–12.064 | 5 | 2.368 | 0.001* | 1.159–3.553 | 2.311 | 0.315 | 0.450–11.865 |
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*; HPF: high-power fields.
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