Research Article
CYP7A1 Gene Polymorphism Located in the 5′ Upstream Region Modifies the Risk of Coronary Artery Disease
Table 3
Distribution of the genotypes and alleles of the rs7833904 polymorphism in the male subgroups of coronary artery disease (CAD) patients and controls.
| | Genotype/allele | CAD
| Control
| Model | OR (CI 95%), | | (%) | (%) |
| | TT | 29 (21.02%) | 57 (36.54%) | Additive | 1 | | AT | 66 (47.82%) | 71 (45.51%) | 1.82 (1.04–3.19), 0.047* | | AA | 43 (31.16%) | 28 (17.95%) | 3.01 (1.57–5.79), 0.001* | AA + AT
TT | 109 (78.98%)
29 (21.02%) | 99 (63.46%)
57 (36.54%) | Dominant | 2.16 (1.28–3.65), 0.005*
1 | AT + TT
AA | 95 (68.84%)
43 (31.16%) | 128 (82.05%)
28 (17.95%) | Recessive | 0.48 (0.28–0.83), 0.012*
1 |
| | A | 152 (55.07%) | 127 (40.70%) | | 1.79 (1.28–2.48), 0.0006* vs T | | T | 124 (44.93%) | 185 (59.3%) | | 0.56 (0.40–0.77), 0.0006* vs A |
|
|
*—statistically significant differences between groups.
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