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Research Article

CYP7A1 Gene Polymorphism Located in the 5′ Upstream Region Modifies the Risk of Coronary Artery Disease

Table 3

Distribution of the genotypes and alleles of the rs7833904 polymorphism in the male subgroups of coronary artery disease (CAD) patients and controls.

Genotype/alleleCAD
Control
ModelOR (CI 95%),
(%) (%)

TT29 (21.02%)57 (36.54%)Additive1
AT66 (47.82%)71 (45.51%)1.82 (1.04–3.19), 0.047*
AA43 (31.16%)28 (17.95%)3.01 (1.57–5.79), 0.001*
AA + AT
TT
109 (78.98%)
29 (21.02%)
99 (63.46%) 
57 (36.54%)
Dominant2.16 (1.28–3.65), 0.005*
1
AT + TT
AA
95 (68.84%)
43 (31.16%)
128 (82.05%)
28 (17.95%)
Recessive0.48 (0.28–0.83), 0.012*
1

A152 (55.07%)127 (40.70%)1.79 (1.28–2.48), 0.0006* vs T
T124 (44.93%)185 (59.3%)0.56 (0.40–0.77), 0.0006* vs A

*—statistically significant differences between groups.

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