Monocyte Proteomics Reveals Involvement of Phosphorylated HSP27 in the Pathogenesis of Osteoporosis
Table 1
Baseline traits and BMD measurements of participants (iTRAQ and validation groups).
Parameter
Premenopausal women
Postmenopausal women
Low BMD ()
High BMD ()
value
Low BMD ()
High BMD ()
value
iTRAQ group
Age (years)
36.1 ± 1.2
36 ± 1.1
ns
55.7 ± 1.1
53.8 ± 0.8
ns
BMI (Kg/m2)
24.7 ± 0.9
26.3 ± 0.6
ns
26.3 ± 0.8
28.5 ± 1.1
ns
BMD at hip (g/cm2)
0.796 ± 0.02
1.07 ± 0.01
<0.0001
0.699 ± 0.02
1.008 ± 0.02
<0.0001
BMD at spine (g/cm2)
0.980 ± 0.05
1.247 ± 0.03
<0.0001
0.796 ± 0.03
1.154 ± 0.02
<0.0001
score hip
−1.5 ± 0.13
0.76 ± 0.09
<0.0001
−2.33 ± 0.14
0.23 ± 0.17
<0.0001
score spine
−1.66 ± 0.12
0.57 ± 0.24
<0.0001
−3.2 ± 0.22
−0.16 ± 0.18
<0.0001
OPP/OP/N
OP = 10
—
OPP = 9, OP = 1
—
Validation group
Age (years)
35.7 ± 0.8
34.8 ± 1.2
ns
54.2 ± 0.9
53.6 ± 0.9
ns
BMI (Kg/m2)
23.8 ± 0.9
25.6 ± 1.2
ns
24.9 ± 0.9
25.3 ± 0.5
ns
BMD at hip (g/cm2)
0.805 ± 0.01
1.075 ± 0.02
<0.0001
0.707 ± 0.02
1.053 ± 0.02
<0.0001
BMD at spine (g/cm2)
1.063 ± 0.04
1.219 ± 0.03
0.0029
0.840 ± 0.02
1.189 ± 0.03
<0.0001
score hip
−1.5 ± 0.11
0.79 ± 0.16
<0.0001
−2.21 ± 0.22
0.61 ± 0.15
<0.0001
score spine
−0.97 ± 0.24
0.31 ± 0.23
0.0033
−2.84 ± 0.20
0.08 ± 0.23
<0.0001
OPP/OP/N
OP = 10
—
OPP = 8, OP = 2
—
Values are mean ± SEM, ns is not significant, BMD is Bone Mineral Density, BMI is Body Mass Index, OPP stands for osteoporosis, OP stands for osteopenia, and N stands for normal.
