Inhibition of HIF-1α Affects Autophagy Mediated Glycosylation in Oral Squamous Cell Carcinoma Cells

Figure 1

HIF-1α inhibitor PX-478 reduces cellular autophagy in Tca8113 cells. (a) Representative western blots showing LC3-II and LC3-I in PX-478 treated Tca8113 cells. Tca8113 cells were treated with 0, 5, and 25 μM PX-478 for 24 h. (b) Quantification of the amount of LC3-II and LC3-I (, Student’s -test). The data are presented as mean ± SD for three independent experiments. (c) Autophagosome could be seen to have variation with 0, 5, and 25 μM PX-478 treated cells (400x).

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