Blockade of Aquaporin 1 Inhibits Proliferation, Motility, and Metastatic Potential of Mesothelioma In Vitro but not in an In Vivo Model

Figure 3

AQP1 blockade decreases cell motility of H226 cells in a wound-healing assay. (a) Migration of cells in a scratch assay is decreased in H226 cells treated with AqB050. Vehicle, ; 20 μM AqB050, ; 40 μM AqV050, ; 80 μM AqB050, . Analysis by repeated measures ANOVA with Tukey’s post hoc analysis (20 μM , 40 μM , and 80 μM ; significance indicated by ∗); error bars: SD. The position of 10 individual cells was tracked over 12 h by time-lapse photography. (b) Vehicle control medium. (c) 80 μM AqB050 treatment.

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